Open AccessInhibitory Effect of (—)‐Epigallocatechin Gallate on Carcinogenesis with N‐Ethyl‐N′‐nitro‐N‐nitrosoguanidine in Mouse Duodenum
Author(s) -
Fujita Yoshihiro,
Yamane Tetsuro,
Tanaka Masumi,
Kuwata Katsuya,
Okuzumi Junichi,
Takahashi Toshio,
Fujiki Hirota,
Okuda Takuo
Publication year - 1989
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1989.tb01666.x
Subject(s) - carcinogenesis , duodenum , epigallocatechin gallate , anticarcinogen , tumor promotion , gallate , gastrointestinal tract , polyphenol , methylnitronitrosoguanidine , chemistry , biology , medicine , cancer research , pharmacology , biochemistry , cancer , gene , antioxidant , mutant
(—)‐Epigallocatechin gallate (EGCG) is the main polyphenolic constituent of green tea infusion and inhibits tumor promotion by teleocidin in two‐stage carcinogenesis on mouse skin. In this work, EGCG was found to inhibit tumor promotion in the gastrointestinal tract in a model system of mouse duodenal carcinogenesis with N‐ethyl‐N′‐nitro‐N‐nitrosoguanidine. The duodenal tumors that developed were studied stereomicroscopically and histologically.