Open AccessKinetic Evaluation of 11 C‐1‐Aminocyclopentane Carboxylic Acid in Rabbits Bearing VX‐2 Tumors Using Positron Emission Tomography
Author(s) -
Fujiwara Takehiko,
Matsuzawa Taiju,
Kawai Hiroaki,
Kawashima Ryuta,
Itoh Masatoshi,
Watanuki Syoichi,
Takahashi Toshihiro,
Iwata Ren,
Ido Tatsuo
Publication year - 1989
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1989.tb01663.x
Subject(s) - positron emission tomography , in vivo , hepatic tumor , chemistry , nuclear medicine , carboxylic acid , radiochemistry , pathology , medicine , biology , biochemistry , microbiology and biotechnology
Tumor detection with 11 C‐1‐aminocyclopentane carboxylic acid ( 11 ‐ACPC) showed that this amino acid has a high affinity for malignant tumors. We studied the kinetics of intravenously injected 11 C‐ACPC in the rabbit VX‐2 tumor using positron emission tomography. Three female rabbits bearing VX‐2 tumor in the thighs were used. High uptake of 11 C‐ACPC was seen in the tumor and liver. 11 ‐ACPC in plasma decreased rapidly after injection and its activity in the tumor increased with time. The kinetic evaluation of ACPC uptake into the tumor was performed using the unidirectional transport model. The average values of the transfer constant of 11 C‐ACPC for VX‐2 tumor were 0.030±0.002 ml/min/g. This preliminary result may form the basis for a quantitative analysis of the in vivo distribution of 11 C‐labeled ACPC in tumors.