Open AccessInduction of Lymphoma in CDF 1 Mice by the Food Mutagen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐ b ]pyridine
Author(s) -
Esumi Hiroyasu,
Ohgaki Hiroko,
Kohzen Emiko,
Takayama Shozo,
Sugimura Takashi
Publication year - 1989
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1989.tb01651.x
Subject(s) - mutagen , carcinogen , pyridine , lymphoma , chemistry , biology , medicine , biochemistry , medicinal chemistry
The mutagenic compound, 2‐amino‐l‐methyl‐6‐phenylimidazo[4,5‐ b ]pyridine (PhIP), originally isolated from cooked beef, was tested for carcinogenicity in CDF 1 mice of both sexes. When PhIP was given in the diet at a concentration of 0.04%, high incidences and early appearances of lymphomas were observed in both sexes during the 579‐day experiment.