Open AccessModulation of 7,12‐Dimethylbenz[ a ]anthracene‐induced Transmammary Carcinogenesis by Disulfiram and Butylated Hydroxyanisole in Mice
Author(s) -
Rao Araga Ramesha,
Hussain Syed Perwez,
Jannu Laxminarayana
Publication year - 1989
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1989.tb01650.x
Subject(s) - butylated hydroxyanisole , dmba , disulfiram , 7,12 dimethylbenz[a]anthracene , carcinogenesis , medicine , endocrinology , chemistry , anthracene , pharmacology , biochemistry , cancer , antioxidant , organic chemistry
The individual as well as combined chemopreventive actions of disulfiram (DSF) and butylated hydroxyanisole (BHA) on 7,12‐dimethylbenz[a]anthracene (DMBA)‐induced transmammary car‐cinogenesis in mice were examined. When nursing mothers receiving normal diet were treated with DMBA (1 mg/mouse) on days 6, 8 and 10 postpartum , the tumor incidence in their 50‐week‐old F 1 progeny was 44.1%. When nursing mothers receiving 0.75% BHA diet, 0.5% DSF diet and 0.75% BHA+0.5% DSF diet were similarly treated with DMBA, the tumor incidences in their 50‐week‐old F 1 progeny were 14.7% ( P <0.05), 12.5% ( P <0.05) and 5.8% ( P <0.01), respectively. It is concluded that diets containing BHA (0.75%) and DSF (0.5%), singly or in combination, can inhibit trans‐mammary carcinogenesis in Swiss albino mice.