Open AccessEffect of Adriamycin on DNA, RNA and Protein Biosyntheses in Mouse Tissues, in Connection with Its Cardiotoxicity
Author(s) -
Sazuka Yasuyuki,
Tanizawa Hisayuki,
Takino Yoshio
Publication year - 1989
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1989.tb01640.x
Subject(s) - cardiotoxicity , rna , dna , enzyme , kidney , biochemistry , biology , biosynthesis , protein biosynthesis , microbiology and biotechnology , dna synthesis , glutathione peroxidase , glutathione , toxicity , endocrinology , medicine , gene
We examined whether the cause of the remarkable decreases in the activities of lipid peroxidationpreventive enzymes in the heart of adriamycin (ADR)‐treated mice might be related to inhibition of DNA, RNA or protein biosynthesis. It was found that biosyntheses of DNA, RNA and protein in the heart, liver and kidney of mice were markedly inhibited by ADR (15 mg/kg, ip). The inhibitory effects of ADR on each type of biosynthesis were particularly marked in the heart among the tissues examined. Strong correlations between the percentage inhibition of DNA and protein biosynthesis by ADR, and the percentage decrease in the activities of lipid peroxidationpreventive enzymes were observed in the heart, liver, kidney and lung, especially for the decrease of glutathione peroxidase activity and the inhibition of DNA and protein biosyntheses. We also found that marked decreases of DNA, RNA and protein biosyntheses in ADR‐treated mice occurred not only in the heart but also in tumor tissues. From these results, we conclude that the increment of cardiac lipid peroxide in ADR‐treated mice, which is closely related to the cardiotoxicity of ADR, results from inhibition of DNA, RNA and protein biosyntheses after the distribution of ADR.