open-access-imgOpen AccessDensity of GM3 with Normal Primary Structure Determines Mouse Melanoma Antigenicity; a New Concept of Tumor Antigen
Harada Yoshitada,
Sakatsume Minoru,
Nores Gustavo A.,
Hakomori Senitiroh,
Taniguchi Masaru
Publication year1989
Publication title
japanese journal of cancer research
Resource typeJournals
We attempted to induce anti‐melanoma cytotoxic T cells (CTL) and suppressor T cells (Ts) inhibiting CTL generation by using liposomes carrying various densities of GM3 as tumor antigens. We found that liposomes carrying 6–16 mol% of GM3 with normal primary structure successfully generated anti‐melanoma CTL and suppressor T cells, while liposomes with GM3 outside this range had little or no such activity. Anti‐melanoma CTL induced by GM3(NeuGc)‐liposomes belonged to CD4 ‐ /CD8 ‐ double‐negative CD3 + CTL while GM3(NeuAc)‐liposomes induced two types of T cells, CD4 + T cells and double‐negative I‐J positive T cells which mediated inhibition of the induction of anti‐melanoma CTL responses. These cell types were tbe same as those induced by mitomycin C‐treated melanoma cells for CTL induction and soluble melanoma antigen for Ts generation. The results clearly demonstrate that even GM3 with normal primary structure can, at a certain density, generate melanoma antlgenicity.
Subject(s)antigen , antigenicity , biochemistry , biology , cancer research , cd8 , ctl* , cytotoxic t cell , immunology , in vitro , liposome , melanoma , microbiology and biotechnology
SCImago Journal Rank2.035

Seeing content that should not be on Zendy? Contact us.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here