Open AccessMEDULLASIN INDUCES ACTIVATED KILLER CELLS FROM HUMAN LYMPHOCYTES
Author(s) -
Aoki Yosuke
Publication year - 1988
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1988.tb02223.x
Subject(s) - serine protease , protease , lysis , natural killer cell , bone marrow , microbiology and biotechnology , biology , lymphocyte , immunology , chemistry , enzyme , biochemistry , cytotoxic t cell , in vitro
Treatment of human lymphocytes with a physiological amount of medullasin, a serine protease found in bone marrow cells, resulted in the induction of activated killer cells which can lyse both natural killer‐sensitive and ‐resistant target cells. The optimum concentration of medullasin was 20 μg/ml when lymphocytes were treated with the protease at 37° for 60 min. Kinetic studies of the induction revealed that the maximum induction was achieved 24 hr after medullasin treatment.