Open AccessINDUCTION AND PROMOTION OF γ‐GLUTAMYLTRANSPEPTIDASE‐POSITIVE FOCI IN THE RAT LIVER BY METHYLGLYOXAL
Author(s) -
Martelli Antonietta,
Ghia Marco,
Mereto Eugenio,
Marinari Umberto Maria,
Brambilla Giovanni
Publication year - 1988
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1988.tb02218.x
Subject(s) - methylglyoxal , medicine , lactoylglutathione lyase , endocrinology , gamma glutamyltransferase , tumor promotion , chemistry , biochemistry , enzyme , cancer , carcinogenesis
The effect of pre‐(initiation) and post‐(promotion) administration of methylglyoxal (MG) on the induction of γ‐glutamyltranspeptidase (GGT)‐positive foci in the liver of F344 male rats was investigated. GGT‐positive foci were produced in doserelated amounts by 0.05 and 0.2% MG in drinking water, either when administered to uninitiated rats or when given in the promotion phase.