Open AccessLEVELS OF GLUTATHIONES TRANSFERASE π mRNA IN HUMAN LUNG CANCER CELL LINES CORRELATE WITH THE RESISTANCE TO CISPLATIN AND CARBOPLATIN
Author(s) -
Nakagawa Kazuhiko,
Yokota Jun,
Wada Makio,
Sasaki Yasutsuna,
Fujiwara Yasuhiro,
Sakai Masaharu,
Muramatsu Masami,
Terasaki Takeo,
Tsunokawa Youko,
Terada Masaaki,
Saijo Nagahiro
Publication year - 1988
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1988.tb01590.x
Subject(s) - cisplatin , carboplatin , cell culture , lung cancer , biology , cancer research , small cell lung carcinoma , cell , intracellular , chemotherapy , microbiology and biotechnology , medicine , small cell carcinoma , genetics
The amounts of mRNA for glutathione S transferase π (GST π) were significantly lower in 3 human small cell lung cancer (SCLC) cell lines than in 3 non small cell lung cancer (NSCLC) cell lines. The sensitivities of the 3 SCLC cell lines to cisplatin and carboplatin were much higher than those of the 3 NSCLC cell lines. These results indicate that low levels of GST π mRNA expression in SCLC cell lines inversely correlate to high sensitivity to cisplatin and carboplatin, and further suggest that GST π may play an important role in intracellular inactivation of these drugs.