Open AccessValidity of Short‐term Examination for Antipromoters of Bladder Carcinogenesis
Author(s) -
Kakizoe Tadao,
Takai Kazuhiro,
Tobisu Kenichi,
Ohtani Mikinobu,
Sato Shigeaki
Publication year - 1988
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1988.tb01581.x
Subject(s) - ascorbic acid , sodium ascorbate , medicine , chemistry , pharmacology , endocrinology , food science
Various compounds were screened for antipromoter activity in bladder carcinogenesis in rats with a view to using them clinically to inhibit postoperative intravesical ectopic tumor growth of superficial papillary bladder cancer. Their inhibitions of the effect of sodium saccharin in maintaining increased agglutinability of bladder cells by concanavalin A were examined in 4‐week tests. The compounds found to inhibit the effect of saccharin were α‐tocopherol, ascorbic acid, aspirin, all‐ trans aromatic retinoid, α‐difluoromethylornithine, sodium cyanate and p, p′ ‐diaminodiphenylmethane. Considering the toxicities of some of these chemicals, ascorbic acid and α‐difluoromethylornithine were concluded to be the most promising for future clinical trials.