Open AccessIMMOBILIZED DATURA STRAMONIUM AGGLUTININ COLUMN CHROMATOGRAPHY, A NOVEL METHOD TO DISCRIMINATE THE URINARY hCGs OF PATIENTS WITH INVASIVE MOLE AND CHORIOCARCINOMA FROM THOSE OF NORMAL PREGNANT WOMEN AND PATIENTS WITH HYDATIDIFORM MOLE
Author(s) -
Endo Tamao,
Iino Koichi,
Nozawa Shiro,
Iizuka Rihachi,
Kobata Akira
Publication year - 1988
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1988.tb01572.x
Subject(s) - datura stramonium , choriocarcinoma , mole , chromatography , urinary system , urine , chemistry , human chorionic gonadotropin , agglutinin , medicine , endocrinology , biochemistry , hormone , psychiatry , lectin
Datura stramonium agglutinin (DSA) binds the asparagine‐linked sugar chains commonly found in the human chorionic gonadotropin (hCG) purified from urine of patients with invasive mole or choriocarcinoma, but not in that of normal pregnant women or patients with hydatidiform mole. With the use of an immobilized DSA column, a novel method to discriminate urinary hCGs from various trophoblastic diseases was developed.