Open AccessNEW HERITABLE FRAGILE SITE ON CHROMOSOME 8 INDUCED BY DISTAMYCIN A
Author(s) -
Ochi Hisako,
Watanabe Shaw,
Yamamoto Hiroshi
Publication year - 1988
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1988.tb01568.x
Subject(s) - chromosomal fragile site , breakpoint , locus (genetics) , biology , genetics , chromosome , cytogenetics , microbiology and biotechnology , gene
A possible new heritable fragile site at band 8q24.1, which is known to be a breakpoint in various cancers and contains the c‐myc locus, was found in the lymphocytes from a woman with mastopathy. This fragile site was induced by distamycin A treatment, and expressed as gaps and breaks in 18% of the metaphases examined. The lymphocytes from one of her two sons examined also revealed gaps or breaks at the same site of chromosome 8 in 34% of the metaphases. This fragile 8q24.1 band is considered to be a new heritable fragile site induced by distamycin A.