Open AccessRadiation, Hyperthermia, and Their Combination in Treatment of Chemically Induced Autochthonous Tumors in Mice
Author(s) -
Sato Setsu,
Ootsuyama Akira,
Tanooka Hiroshi
Publication year - 1988
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1988.tb01567.x
Subject(s) - hyperthermia , radiation therapy , irradiation , medicine , ratón , nuclear medicine , pathology , cancer research , nuclear physics , physics
All autochthonous tumors induced chemically in the thighs of C3H/He mice showed recurrence after single X‐irradiation with 20–60 Gy when they were 10 mm in diameter, although this treatment caused temporary, dose‐dependent regression. Hyperthermia for 30 min at 43.0° alone had little effect. However, in 2 of 16 mice, hyperthermia after irradiation at 60 Gy resulted in complete cure, i.e., survival of mice without recurrence for more than 120 days after treatment. These results indicate that the combined treatment of radiation and hyperthermia is necessary to obtain the cure of mouse autochthonous tumors.