Open AccessA Case‐Control Study of the Effectiveness of Cervical Cancer Screening in Osaka, Japan
Author(s) -
Sobue Tomotaka,
Suzuki Takaichiro,
Hashimoto Sumiyo,
Yokoi Nobuko,
Fujimoto Isaburo
Publication year - 1988
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1988.tb01555.x
Subject(s) - medicine , cervical cancer , papanicolaou stain , incidence (geometry) , cancer , odds ratio , obstetrics , gynecology , case control study , population , physics , environmental health , optics
In the small town of Nose in Osaka, Japan, a population‐based screening program for cervical cancer by Papanicolaou smear has been conducted since 1965. In order to evaluate the effectiveness of screening in terms of the reduction of the mortality and the incidence of invasive cervical cancer, two types of case‐control studies were carried out. In the first study, the case series consisted of all women who died of cervical cancer under 80 years of age at the time of diagnosis in 1965‐1987 (N = 15). For each case, 10 controls were chosen from living residents, matched by year of birth. It showed that the odds ratio (OR) of dying of cervical cancer for screened versus non‐screened women was 0.22 (95%CI = 0.03‐1.95). In the second study, the case series consisted of all women who were diagnosed as having invasive cancer under 80 years of age at the time of diagnosis in the same period (N = 28). For each case, 10 controls were chosen from living residents without invasive cancer, matched by year of birth and according to whether or not they were screened at the year of the diagnosis of the matched case. It showed that the OR of getting invasive cancer for screened versus non‐screened women was 0,41 (95%CI = 0.13‐1.29). From these results, it was estimated that 78% of cervical cancer mortality and 59% of invasive cervical cancer incidence among non‐screened women could be prevented by cervical cancer screening.