Open AccessPRODUCTION OF PARATHYROID HORMONE‐RELATED PROTEIN IN ADULT T‐CELL LEUKEMIA CELLS
Author(s) -
Honda Satoshi,
Yamaguchi Ken,
Miyake Yoshio,
Hayashi Nakanobu,
Adachi Naoto,
Kinoshita Kenichiro,
Ikehara Osamu,
Kimura Satoshi,
Kinoshita Tomohiro,
Shimotohno Kunitada,
Shimoyama Masanori,
Abe Kaoru
Publication year - 1988
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1988.tb01554.x
Subject(s) - parathyroid hormone related protein , radioimmunoassay , t cell leukemia , cell culture , leukemia , parathyroid hormone , medicine , endocrinology , messenger rna , biology , hormone , cell , cancer research , microbiology and biotechnology , gene , calcium , biochemistry , genetics
Human parathyroid hormone‐related protein (PTHrP) mRNA was detected in peripheral leukemic cells obtained from adult T‐cell leukemia (ATL) patients as well as in cultured human T‐cell leukemia virus type I (HTLV‐D‐infected T‐cell lines. In contrast, PTHrP mRNA was not detected in other types of leukemic cells. Using radioimmunoassay, immunoreactive PTHrP was also detected in the spent media of HTLV‐I‐infected T‐cell lines. These results suggest that PTHrP plays an important role in developing the hyperealcemia frequently observed in ATL patients.