Open AccessInductions of Ornithine Decarboxylase and DNA Synthesis in Rat Stomach Mucosa by Formaldehyde
Author(s) -
Furihata Chie,
Yamakoshi Akira,
Matsushima Taijiro
Publication year - 1988
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1988.tb00055.x
Subject(s) - stomach , ornithine decarboxylase , gastric mucosa , formaldehyde , endocrinology , dna synthesis , medicine , chemistry , carboxy lyases , biology , dna , biochemistry , enzyme
Administration of formaldehyde at doses of 11 to 110 rag/kg body weight by gastric intubation to male F344 rats induced up to 100‐fold increase in ornithine decarboxylase activity with a maximum after 16 hr and up to 49‐fold increase in DNA synthesis with a maximum after 16 hr in the pyloric mucosa of the stomach. These results suggest that formaldehyde has tumor‐promoting activity in carcinogenesis in the glandular stomach.