Open AccessA SYNTHETIC ADJUVANT EFFECTIVE IN INDUCING ANTITUMOR IMMUNITY
Author(s) -
Kataoka Tetsuro,
Tokunaga Tohru
Publication year - 1988
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1988.tb00042.x
Subject(s) - muramyl dipeptide , adjuvant , saline , immunity , medicine , dipeptide , chemistry , immunology , pharmacology , cancer research , immune system , biochemistry , peptide
Guinea pigs which were injected repeatedly with a mixture of a 3 M KC1 extract of line 10 tumor and 6‐O‐(2‐tetradecyl‐hexadecanoyl)‐muramyl‐dipeptide (B30‐MDP) rejected a tumor graft of line 10. Such an adjuvant effect of B30‐MDP was also demonstrated when X‐ray‐treated line 10 cells were mixed with B30‐MDP dissolved in phosphatebuffered saline and inoculated into the animals.