Open AccessMORPHOLOGIC CHANGES OF NEUTROPHILS IN MYELODYSPLASTIC SYNDROME TREATED WITH RECOMBINANT HUMAN GRANULOCYTE COLONY‐STIMULATING FACTOR
Author(s) -
Toyama Keisuke,
Ohyashiki Kazuma,
Ohyashiki Junko H.,
Takaku Fumimaro
Publication year - 1988
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1988.tb00041.x
Subject(s) - granulocyte colony stimulating factor , granulocyte , medicine , discontinuation , granulocyte colony stimulating factor receptor , recombinant dna , clone (java method) , myelodysplastic syndromes , immunology , granulocyte macrophage colony stimulating factor , absolute neutrophil count , neutrophile , chemotherapy , biology , cytokine , neutropenia , inflammation , bone marrow , gene , biochemistry
Two cases of myelodysplastic syndrome (MDS) were treated with recombinant human granulocyte colony‐stimulating factor (rhG‐CSF). In both cases, an increase of peripheral neutrophil counts was noted with a peak within 12 hr after the rhG‐CSF administration. Neutrophils with ring shaped or hypersegmented nuclei were noted in the peripheral blood during the treatment, and they disappeared promptly after discontinuation of the therapy. The results indicate that the rhG‐CSF might have mobilizing and differentiating effects on neutrophils derived from the MDS clone.