Open AccessA MONOCLONAL ANTIBODY THAT RECOGNIZES A COMMON ANTIGEN IN MYELOID AND HUMAN T‐CELL LEUKEMIA VIRUS TYPE I‐CARRYING CELLS
Author(s) -
Takeuchi Tamotsu,
Kubonishi Ichiro,
Takahashi Kiyoshi,
Ohtsuki Yuji,
Taguchi Hirokuni,
Miyoshi Isao
Publication year - 1988
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1988.tb00040.x
Subject(s) - monoclonal antibody , antigen , myeloid leukemia , leukemia , virology , myeloid , biology , antibody , lymphoma , cell culture , monoclonal , immunology , genetics
A novel monoclonal antibody, designated D‐213, was generated to human myeloid cell line PL‐21. D‐213 defined a 47‐kD antigen which was specifically expressed in normal and leukemic cells of the myeloid lineage and in T‐cell lines carrying human T‐cell leukemia virus type I. This antibody was also reactive with adult T‐cell leukemia/lymphoma (ATLL) cells in formalin‐fixed, paraffin‐embedded tissues. D‐213 would be useful for making an immunohistochemical diagnosis of ATLL in cases where serological or virological information is not available.