Open AccessCELL‐LINE SPECIFIC ACTIVATION OF SV40 TRANSCRIPTIONAL ENHANCER BY p40 tax OF HTLV‐1
Author(s) -
Fujisawa Junichi,
Seiki Motoharu,
Toita Masami,
Miyatake Shoichiro,
Arai Kenichi,
Yoshida Mitsuaki
Publication year - 1988
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1988.tb00038.x
Subject(s) - enhancer , cell culture , enhancer rnas , activator (genetics) , rous sarcoma virus , biology , in vitro , microbiology and biotechnology , virus , virology , gene expression , gene , genetics
A transcriptional trans ‐activator P40 tax of HTLV‐1 was reported to activate HTLV‐1 enhancer, but not SV40 or Rous sarcoma virus enhancer. However, in certain cell lines, we found that SV40 enhancer was activated by p40 tax . These cell lines were mostly T cells, where the SV40 enhancer showed only low activity without p40 tax . Since p40 tax ‐mediated activation of the LTR is not cell line‐specific, the activation of enhancers by p40 tax depends on the combination of enhancer and cell type used for the test. Thus, apparent activation by p40 tax depends on variable cellular components involved in transcriptional regulation.