Open AccessHepatocellular Tumorigenicity of Butylated Hydroxytoluene Administered Orally to B6C3F 1 Mice
Author(s) -
Inai Kouki,
Kobuke Toshihiro,
Nambu Shigeru,
Takemoto Tsuyoshi,
Kou Eihaku,
Nishina Hajime,
Fujihara Megumu,
Yonehara Shoji,
Suehiro Shinichi,
Tsuya Takafumi,
Horiuchi Kenji,
Tokuoka Shoji
Publication year - 1988
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1988.tb00010.x
Subject(s) - butylated hydroxytoluene , carcinogen , oral administration , medicine , hepatocellular adenoma , adenoma , butylated hydroxyanisole , anticarcinogen , endocrinology , ratón , pharmacology , antioxidant , biology , biochemistry , carcinogenesis , cancer
Butylated hydroxytoluene (BHT), a preservative widely found in food as a food additive, was orally administered at concentrations of 1% and 2% of the diet to B6C3F 1 mice for 104 consecutive weeks. Treated animals underwent a 16‐week recovery period prior to pathological examination. In male mice administered BHT, the incidence of mice with either a hepatocellular adenoma or a focus of cellular alteration in the liver was increased in a clear dose‐response relationship. The incidences of male mice with other tumors and the incidences of female mice with any tumor were not significantly increased as a consequence of BHT administration. The results of this study indicate BHT to be tumorigenic to the liver of the B6C3F 1 male mouse.