Open AccessGALLIUM CITRATE, A NEW SENSITIZER OF CELLS TO HYPERTHERMIA
Author(s) -
Shinohara Kunio,
Kawakami Noriko,
Kugotani Maho,
Nakano Hisako
Publication year - 1988
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1988.tb00006.x
Subject(s) - gallium , hyperthermia , chemistry , medicine , cancer research , organic chemistry
The killing effects of heat were studied on cultured mammalian cells (L5178Y) pre‐incubated with gallium (Ga) citrate, which is a popular tumor‐imaging diagnostic agent. The cells showed higher sensitivity to heat when they were pre‐incubated with Ga‐citrate. The pre‐incubated cells showed decreased ATP levels, and this may be responsible for the heat‐sensitizing effect.