Open AccessPRELIMINARY OBSERVATION ON PANCREATIC DUCT ADENOCARCINOMA INDUCED BY INTRADUCTAL ADMINISTRATION OF N‐ETHYL‐N′ ‐NITRO‐N‐NITROSOGUANIDINE IN DOGS
Author(s) -
Kamano Toshiki,
Azuma Noboru,
Katami Atsuo,
Tamura Junji,
Sakakibara Noburu,
Matsumoto Michio,
Mizumoto Kazuhiro,
Kitazawa Shunji,
Konishi Yoichi
Publication year - 1988
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1988.tb00001.x
Subject(s) - adenocarcinoma , medicine , pancreatic duct , pancreatic disease , gastroenterology , duct (anatomy) , pathology , general surgery , pancreas , cancer
Pancreatic duct adenocarcinoma was induced by intraductal administration of N‐ethyl‐N′‐nitro N‐nitrosoguanidine (ENNG) in two mongrel dogs. A dog received a total dose of 595 mg of ENNG during 12 months and was sacrificed. Duct obstruction was detected by pancreatography and duct adenocarcinoma was found. Another dog was given a total dose of 350 mg of ENNG during 8 months and was sacrificed 26 months after the first administration of the carcinogen. Duct adenocarcinoma was found. No pancreatic tumors were found in 2 dogs given intraperitoneal N‐nitrosobis(2‐oxo‐propyl)amine at a total dose of 4000 mg or in 2 dogs given Tween 60 only. These results suggest that the direct presence of a carcinogen in the pancreatic duct was able to induce duct adenocarcinoma in dogs.