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Antigen 85A and mycobacterial DNA‐binding protein 1 are targets of immunoglobulin G in individuals with past tuberculosis
Author(s) -
OsadaOka Mayuko,
Tateishi Yoshitaka,
Hirayama Yukio,
Ozeki Yuriko,
Niki Mamiko,
Kitada Seigo,
Maekura Ryoji,
Tsujimura Kunio,
Koide Yukio,
Ohara Naoya,
Yamamoto Taro,
Kobayashi Kazuo,
Matsumoto Sohkichi
Publication year - 2013
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2012.12005.x
Subject(s) - tuberculosis , antigen , mycobacterium tuberculosis , antibody , immunology , biology , asymptomatic , immunoglobulin g , latent tuberculosis , medicine , pathology
Development of accurate methods for predicting progression of tuberculosis (TB) from the latent state is recognized as vitally important in controlling TB, because a majority of cases develop from latent infections. Past TB that has never been treated has a higher risk of progressing than does latent Mycobacterium tuberculosis infection in patients who have previously received treatment. Antibody responses against 23 kinds of M. tuberculosis proteins in individuals with past TB who had not been medicated were evaluated. These individuals had significantly higher concentrations of antibodies against Antigen 85A and mycobacterial DNA‐binding protein 1 (MDP1) than did those with active TB and uninfected controls. In addition, immunohistochemistry revealed colocalization of tubercle bacilli, antigen 85 and MDP1 inside tuberculous granuloma lesions in an asymptomatic subject, showing that M. tuberculosis in lesions expresses both antigen 85 and MDP1. Our study suggests the potential usefulness of measuring antibody responses to antigen 85A and MDP1 for assessing the risk of TB progression.