Premium
Cross‐reactive antibody response to the pandemic A (H1N1) 2009 influenza virus induced by vaccination with a seasonal trivalent influenza vaccine: a longitudinal study of three influenza seasons in Japan
Author(s) -
Uno Shingo,
Kimachi Kazuhiko,
Matsuo Fujio,
Miyazaki Keiichiro,
Oohama Ayano,
Kei Junko,
Nishimura Tomohiro,
Odoh Koichi,
Kino Yoichiro
Publication year - 2012
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2012.00511.x
Subject(s) - vaccination , virology , hemagglutination assay , pandemic , virus , titer , antibody , biology , human mortality from h5n1 , cross reactivity , influenza a virus , antibody titer , trivalent influenza vaccine , influenza vaccine , immunology , medicine , covid-19 , disease , infectious disease (medical specialty) , cross reactions
The cross‐reactivity of antibody to the swine‐origin pandemic influenza A (H1N1) 2009 virus induced by vaccination with a seasonal trivalent influenza vaccine was studied. Paired sera from a cohort of adult volunteers vaccinated with a trivalent seasonal influenza vaccine every year from 2006 to 2008 were collected each year and tested by hemagglutination inhibition (HI) for antibody against the pandemic influenza A (H1N1) 2009 virus. There was little increase in the geometric mean titer overall; a slight increase was detected in the sera obtained in the 2007–2008 season but not in the other two seasons. The proportion of individuals with HI antibody titers ≥ 1:40 did not change significantly from year to year. These results indicate that cross‐reactivity of the antibodies induced by a trivalent seasonal vaccine to the pandemic influenza A (H1N1) 2009 virus is marginal.