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Immunity induced by Staphylococcus aureus surface protein A was protective against lethal challenge of Staphylococcus aureus in BALB/c mice
Author(s) -
Yi ShaoQiong,
Zhang XiaoYan,
Yang YiLong,
Yang Yue,
Liu ShuLing,
Fu Ling,
Yu ChangMing,
Chen Wei
Publication year - 2012
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2012.00451.x
Subject(s) - staphylococcus aureus , biology , microbiology and biotechnology , immunity , staphylococcal infections , staphylococcus , balb/c , immunology , immune system , bacteria , genetics
Staphylococcus aureus is the most common cause of hospital‐acquired bacteremia. Due to emergence of antibiotic‐resistant strains, these infections present a serious public health threat. In this study, to develop a broadly protective vaccine, we tested whether immune responses induced by several proteins associated with S. aureus toxicity could protect mice from lethal challenge with human clinical S. aureus isolate USA300. We found that the surface protein A (SasA) of S. aureus could protect mice from lethal challenge of the bacteria.