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Iron starvation regulates the type III secretion system in Bordetella bronchiseptica
Author(s) -
Kurushima Jun,
Kuwae Asaomi,
Abe Akio
Publication year - 2012
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2012.00442.x
Subject(s) - bordetella bronchiseptica , bordetella , microbiology and biotechnology , virulence , biology , secretion , virulence factor , type three secretion system , bacteria , starvation , gene , bordetella pertussis , biochemistry , genetics , endocrinology
The type III secretion system (T3SS) plays a key role in the exertion of full virulence by Bordetella bronchiseptica . However, little is known about the environmental stimuli that induce expression of T3SS genes. Here, it is reported that iron starvation is a signal for T3SS gene expression in B. bronchiseptica . It was found that, when B. bronchiseptica is cultured under iron‐depleted conditions, secretion of type III secreted proteins is greater than that in bacteria grown under iron‐replete conditions. Furthermore, it was confirmed that induction of T3SS‐dependent host cell cytotoxicity and hemolytic activity is greatly enhanced by infection with iron‐depleted Bordetella . In contrast, production of filamentous hemagglutinin is reduced in iron‐depleted Bordetella . Thus, B. bronchiseptica controls the expression of virulence genes in response to iron starvation.