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Major histocompatibility complex class I‐restricted cytotoxic T lymphocyte responses during primary simian immunodeficiency virus infection in Burmese rhesus macaques
Author(s) -
Nakamura Midori,
Takahara Yusuke,
Ishii Hiroshi,
Sakawaki Hiromi,
Horiike Mariko,
Miura Tomoyuki,
Igarashi Tatsuhiko,
Naruse Taeko K.,
Kimura Akinori,
Matano Tetsuro,
Matsuoka Saori
Publication year - 2011
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2011.00384.x
Subject(s) - ctl* , simian immunodeficiency virus , biology , virology , major histocompatibility complex , immunology , cytotoxic t cell , mhc class i , cd8 , immunodominance , antigen , virus , epitope , genetics , in vitro
Major histocompatibility complex class I (MHC‐I)‐restricted CD8 + cytotoxic T lymphocyte (CTL) responses are crucial for the control of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replication. In particular, Gag‐specific CTL responses have been shown to exert strong suppressive pressure on HIV/SIV replication. Additionally, association of Vif‐specific CTL frequencies with in vitro anti‐SIV efficacy has been suggested recently. Host MHC‐I genotypes could affect the immunodominance patterns of these potent CTL responses. Here, Gag‐ and Vif‐specific CTL responses during primary SIVmac239 infection were examined in three groups of Burmese rhesus macaques, each group having a different MHC‐I haplotype. The first group of four macaques, which possessed the MHC‐I haplotype 90‐010‐Ie , did not show Gag‐ or Vif‐specific CTL responses. However, Nef‐specific CTL responses were elicited, suggesting that primary SIV infection does not induce predominant CTL responses specific for Gag/Vif epitopes restricted by 90‐010‐Ie ‐derived MHC‐I molecules. In contrast, Gag‐ and Vif‐specific CTL responses were induced in the second group of two 89‐075‐Iw ‐positive animals and the third group of two 91‐010‐Is ‐positive animals. Considering the potential of prophylactic vaccination to affect CTL immunodominance post‐viral exposure, these groups of macaques would be useful for evaluation of vaccine antigen‐specific CTL efficacy against SIV infection.