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Mycoplasma pneumoniae induces interleukin‐8 production via the epidermal growth factor receptor pathway
Author(s) -
Arae Ken,
Hirata Masako,
Kurata Satoshi,
Kamiya Shigeru,
Taguchi Haruhiko
Publication year - 2011
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2011.00375.x
Subject(s) - epidermal growth factor receptor , a549 cell , biology , epiregulin , epidermal growth factor , transfection , small interfering rna , microbiology and biotechnology , interleukin , mycoplasma pneumoniae , interleukin 8 , cancer research , receptor , cytokine , immunology , cell culture , pneumonia , medicine , amphiregulin , biochemistry , genetics
In mycoplasmal pneumonia, the bronchi are histopathologically filled with polymorphonuclear leukocytes. The EGFR pathway is involved in IL‐8 production. We investigated the contribution of the EGFR pathway to IL‐8 production by bronchial epithelial cells (A549) stimulated with Mp‐Ag. The IL‐8 production by A549 cells stimulated with Mp‐Ag was decreased by the addition of an EGFR kinase inhibitor or transfection with small interfering RNA against EGFR. The levels of epiregulin mRNA in A549 cells were increased by stimulation with Mp‐Ag. In conclusion, the EFGR pathway participates in IL‐8 production by bronchial epithelial cells stimulated with Mp‐Ag.