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Remarkable similarity in genome nucleotide sequences between the Schwarz FF‐8 and AIK‐C measles virus vaccine strains and apparent nucleotide differences in the phosphoprotein gene
Author(s) -
Ito Chie,
Ohgimoto Shinji,
Kato Seiichi,
Sharma Luna Bhatta,
Ayata Minoru,
Komase Katsuhiro,
Takeuchi Kaoru,
Ihara Toshiaki,
Ogura Hisashi
Publication year - 2011
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2011.00339.x
Subject(s) - measles virus , biology , phosphoprotein , virology , genome , nucleic acid sequence , genetics , gene , paramyxoviridae , strain (injury) , nucleotide , virus , vaccination , measles , viral disease , anatomy
The Schwarz FF‐8 (FF‐8) and AIK‐C measles virus vaccine strains are currently used for vaccination in Japan. Here, the complete genome nucleotide sequence of the FF‐8 strain has been determined and its genome sequence found to be remarkably similar to that of the AIK‐C strain. These two strains are differentiated only by two nucleotide differences in the phosphoprotein gene. Since the FF‐8 strain does not possess the amino acid substitutions in the phospho‐ and fusion proteins which are responsible for the temperature‐sensitivity and small syncytium formation phenotypes of the AIK‐C strain, respectively, other unidentified common mechanisms likely attenuate both the FF‐8 and AIK‐C strains.