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Mechanism underlying silent cleanup of apoptotic cells
Author(s) -
Kobayashi Yoshiro
Publication year - 2011
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2010.00291.x
Subject(s) - apoptosis , nitric oxide , clearance , biology , microbiology and biotechnology , mechanism (biology) , in vivo , in vitro , infiltration (hvac) , immunology , biochemistry , genetics , medicine , physics , urology , endocrinology , thermodynamics , quantum mechanics
Apoptotic cells are cleared without an inflammatory response such as neutrophil infiltration. The mechanism underlying such silent cleanup of apoptotic cells has been intensively investigated in vitro for over a decade, and the concept that active suppression via IL‐10, TGF‐β, and nitric oxide enables such silent cleanup to occur has been emerging. However, because this concept has not been vigorously examined under a variety of experimental conditions in vivo , the possibility remains that a null response, in which neither cytokines nor nitric oxide is produced upon an encounter with apoptotic cells, is responsible for silent cleanup.