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Effect of total alkaloids from Commelina communis L. on lung damage by influenza virus infection
Author(s) -
Zhang GuoBin,
Bing FeiHong,
Liu Jun,
Li Zhi,
Liao YiFan,
Li Jing,
Dong ChangYuan
Publication year - 2010
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2010.00277.x
Subject(s) - biology , virology , virus , lung , influenza a virus , medicine
Whether administration of total alkaloids from Commelina communis L. (TAC) reduces lung damage in influenza virus‐infected mice was investigated. Compared with untreated mice, significantly less severe damage was found in the lungs of mice administered TAC at 8 mg/kg per day for 6 days. TAC significantly decreased viral loads in the lungs. The concentrations of IFN‐γ in the serum of TAC‐treated mice were significantly lower than those of virus control mice at 4 and 6 days post‐infection. The results indicate that TAC imparted partial protection to the mice by reducing pulmonary viral loads and limiting lesions in the lungs.