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Opposite effects of two nonstructural proteins of Theiler's murine encephalomyelitis virus regulates apoptotic cell death in BHK‐21 cells
Author(s) -
Okuwa Takako,
Taniura Naoko,
Saito Mineki,
Himeda Toshiki,
Ohara Yoshiro
Publication year - 2010
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2010.00260.x
Subject(s) - biology , apoptosis , virology , virus , encephalomyelitis , programmed cell death , baby hamster kidney cell , cell , microbiology and biotechnology , immunology , genetics , multiple sclerosis
Theiler's murine encephalomyelitis virus is divided into two subgroups, TO and GDVII, inducing subgroup‐specific diseases. In order to investigate the role(s) of nonstructural proteins of TMEV, L and L*, leaders of two subgroups, were separately expressed with or without L* in BHK‐21 cells. Expression of L increased the number of apoptotic cells. L*/BHK‐21 cells constitutively expressing L* showed the decrease in cell death induced by L. These results suggest that L and L* regulate apoptosis during viral infection and contribute to TMEV subgroup‐specific biological activities.