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Detection of DNA of six human herpesviruses in the cerebrospinal fluid of immunocompetent non‐herpetic acute limbic encephalitis patients
Author(s) -
Yoshikawa Tetsushi,
Asano Yoshizo,
Takahashi Yukitoshi
Publication year - 2010
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2010.00234.x
Subject(s) - limbic encephalitis , cerebrospinal fluid , encephalitis , human herpesvirus 6 , herpes simplex virus , herpesviridae , biology , virology , virus , immunology , pathology , neuroimaging , viral disease , medicine , neuroscience
In order to determine whether six other human herpesviruses, aside from herpes simplex virus, are associated with non‐herpetic acute limbic encephalitis in immunocompetent individuals, real‐time PCR was used to detect the DNA of herpesviruses in CSF collected from 61 patients with this form of encephalitis. Five of the human herpesviruses tested were not detected in any of the 61 CSF samples. EBV DNA was detected in one CSF sample. The EBV DNA‐positive patient was a 36‐year‐old woman who presented with fever, headache, mild somnolence, and the typical neuroimaging findings.