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Bifidobacterium suppresses IgE‐mediated degranulation of rat basophilic leukemia (RBL‐2H3) cells
Author(s) -
Harata Gaku,
He Fang,
Takahashi Kyoko,
Hosono Akira,
Kawase Manabu,
Kubota Akira,
Hiramatsu Masaru,
Kaminogawa Shuichi
Publication year - 2010
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2009.00185.x
Subject(s) - degranulation , bifidobacterium bifidum , immunoglobulin e , biology , bifidobacterium , microbiology and biotechnology , probiotic , immunology , basophilic , in vitro , lactobacillus , antibody , bacteria , biochemistry , medicine , fermentation , receptor , genetics , pathology
Sixteen heat‐killed bifidobacteria isolated from human intestine and a probiotic strain Lactobacillus GG were tested for their ability to influence IgE‐mediated degranulation of rat basophilic leukemia (RBL‐2H3) cells in vitro . The bifidobacteria suppressed IgE‐mediated degranulation of RBL‐2H3 cells by 1.6–56.4% in a strain‐dependent manner. Bifidobacteria from healthy infants expressed high inhibitory effects on IgE‐mediated degranulation (41–55%), while those from allergic infants varied greatly in their effects against degranulation. Bifidobacteria taxonomically identified as Bifidobacterium bifidum exhibited much stronger inhibitory effects against IgE‐mediated degranulation than those taxonomically identified as B. adolescentis ( P < 0.05).These results indicate that the intestinal bifidobacteria might be one of factors influencing IgE‐mediated allergic responses.