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Intraspecies transmission of L‐type‐like bovine spongiform encephalopathy detected in Japan
Author(s) -
Fukuda Shigeo,
Iwamaru Yoshifumi,
Imamura Morikazu,
Masujin Kentarou,
Shimizu Yoshihisa,
Matsuura Yuichi,
Shu Yujing,
Kurachi Megumi,
Kasai Kazuo,
Murayama Yuichi,
Onoe Sadao,
Hagiwara Ken’ichi,
Sata Tetsutaro,
Mohri Shirou,
Yokoyama Takashi,
Okada Hiroyuki
Publication year - 2009
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2009.00169.x
Subject(s) - bovine spongiform encephalopathy , prion protein , biology , virology , transmission (telecommunications) , incubation period , transmissible spongiform encephalopathy , phenotype , strain (injury) , encephalopathy , disease , incubation , genetics , pathology , scrapie , medicine , gene , anatomy , psychiatry , biochemistry , electrical engineering , engineering
It has been assumed that the agent causing BSE in cattle is a uniform strain (classical BSE); however, different neuropathological and molecular phenotypes of BSE (atypical BSE) have been recently reported. We demonstrated the successful transmission of L‐type‐like atypical BSE detected in Japan (BSE/JP24 isolate) to cattle. Based on the incubation period, neuropathological hallmarks, and molecular properties of the abnormal host prion protein, the characteristics of BSE/JP24 prion were apparently distinguishable from the classical BSE prion and closely resemble those of bovine amyloidotic spongiform encephalopathy prion detected in Italy.