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Increase of regulatory T cells in the peripheral blood of dogs with metastatic tumors
Author(s) -
Horiuchi Yutaka,
Tominaga Makiko,
Ichikawa Mika,
Yamashita Masao,
Jikumaru Yuri,
Nariai Yoko,
Nakajima Yuko,
Kuwabara Masato,
Yukawa Masayoshi
Publication year - 2009
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2009.00144.x
Subject(s) - biology , peripheral blood , peripheral , cancer research , pathology , medicine , immunology
It is well known that lymphocytes from patients with advanced‐stage cancer have impaired immune responsiveness and that type1 T lymphocyte subsets in tumor bearing hosts are suppressed. Treg have been reported to comprise a subgroup which inhibits T cell mediated immune responses. In the present study, the percentage of Treg, Th1 and Tc1 in the peripheral blood of tumor bearing dogs with or without metastases was evaluated. The percentages of Th1 and Tc1 in dogs with metastatic tumor were significantly less, and that of Treg was significantly greater, than those of dogs without metastatic tumor. The percentage of Treg showed an inverse correlation with that of Th1 and Tc1 in tumor bearing dogs. It was concluded that an increase in Treg in the peripheral blood of dogs with metastatic tumor may induce suppression of tumor surveillance by the Type1 immune response and lead to metastasis of tumor[0][0].[0]