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Association between antibody response against cytomegalovirus strain‐specific glycoprotein H epitopes and HLA‐DR
Author(s) -
Ishibashi Kei,
Tokumoto Tadahiko,
Shirakawa Hiroki,
Hashimoto Koichi,
Kushida Nobuhiro,
Yanagida Tomohiko,
Shishido Keiichi,
Aikawa Ken,
Yamaguchi Osamu,
Toma Hiroshi,
Tanabe Kazunari,
Suzutani Tatsuo
Publication year - 2009
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2009.00134.x
Subject(s) - epitope , biology , virology , glycoprotein , cytomegalovirus , human leukocyte antigen , antibody , strain (injury) , immunology , antibody response , antigen , microbiology and biotechnology , virus , herpesviridae , viral disease , anatomy
The gH of CMV is a major target for strain‐specific neutralizing antibodies. To verify whether there is a correlation between HLA‐DR type and strain‐specific antibodies, antibodies against CMV gH in potential donors and recipients for renal transplantation were investigated. Among 471 subjects, 404 (86%) showed reactivity to CMV gH, but no antibodies against gH were detected in 67 (14%) subjects. The positive rates were over 80% in most HLA subpopulations. Fewer subjects with HLA‐DR10 and DR11 had antibodies to CMV gH than did those without HLA‐DR10 and DR11. HLA‐DR10 and DR11 may be associated with fewer/non‐responders for strain‐specific neutralizing antibodies.