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Blood kinetics of four intraperitoneally administered therapeutic candidate bacteriophages in healthy and neutropenic mice
Author(s) -
Uchiyama Jumpei,
Maeda Yoshihiro,
Takemura Iyo,
ChessWilliams Russ,
Wakiguchi Hiroshi,
Matsuzaki Shigenobu
Publication year - 2009
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2009.00125.x
Subject(s) - biology , therapeutic effect , drug , pharmacology , peripheral blood , immunology , kinetics , microbiology and biotechnology , physics , quantum mechanics
Due to multiple‐drug resistant bacteria, phage therapy is being revisited. Although most animal experiments focus on therapeutic efficacy, the blood clearance kinetics of phages have not been well described. For further development of an efficient therapeutic strategy, information on phage blood kinetics is important. In this study, time‐course concentration changes in peripheral blood of healthy and neutropenic mice were measured using four therapeutic phages (φMR11, KPP10, φEF24C, and KEP10). The results showed a two‐ to three‐day rapid phage clearance, which fits a two‐compartment model.