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Molecular Epidemiology of Rabies in Vietnam
Author(s) -
Yamagata Junpei,
Ahmed Kamruddin,
Khawplod Pakamatz,
Mannen Kazuaki,
Xuyen Dinh Kim,
Loi Huynh Huu,
Van Dung Nguyen,
Nishizono Akira
Publication year - 2007
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2007.tb03979.x
Subject(s) - genotype , biology , molecular epidemiology , ho chi minh , phylogenetic tree , epidemiology , vietnamese , rabies , indian subcontinent , gene , virology , veterinary medicine , genetics , socioeconomics , ethnology , low income , medicine , history , linguistics , philosophy , sociology
The present study was done to determine the molecular epidemiology of rabies virus (RV) in Vietnam. The nucleoprotein (N) and glycoprotein (G) genes of RVs were amplified from the brains of ten rabid dogs of Ho Chi Minh City, Vietnam. The nucleotide sequences of these genes were compared with those of other Asian strains to find the possible relationship among them. Phylogenetic analysis revealed that the Asian N gene segregated into three main branches, namely South‐East Asia 1 (SEA 1), South‐East Asia 2 (SEA 2) and Indian subcontinent (ISC) genotypes. The SEA 1 genotype comprised RVs from Malaysia, Vietnam and Thailand. The SEA 2 genotype contained strains from the Philippines, and the ISC genotype comprised strains from Sri Lanka and India. Phylogenetically G genes of RVs from Vietnam and Thailand were clustered together. Our study suggests that Vietnamese and Thai RVs are closely related and might have originated from a common ancestor.