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Differential Effect of Listeria monocytogenes Infection on Cytokine Production and Cytotoxicity of CD8 T Cells
Author(s) -
Maruyama Saho,
Shen Hua,
Kanoh Makoto,
Matsumoto Akira,
Asano Yoshihiro
Publication year - 2007
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2007.tb03972.x
Subject(s) - cytotoxic t cell , biology , il 2 receptor , interleukin 21 , cd8 , immune system , tlr2 , antigen presenting cell , natural killer t cell , cytokine , immunology , microbiology and biotechnology , t cell , innate immune system , in vitro , biochemistry
Bacterial infection induces a shift to type 1 CD4 T cell subset in an infected host and this shift is important for protection of the host from disease development. Many researchers think that the shift is antigen‐dependent, but we previously demonstrated an initial induction step for CD4 T cell subsets during Listeria monocytogenes (Lm) infection is antigen‐independent. Although Listeria is a TLR2 ligand, the immune system of the Lm‐infected host responded to the pathogen to induce expression of CD69 but not CD25 on CD4 T cells, CD8 T cells and B cells even in the absence of TLR2 or MyD88. The antigen‐independent activation of type 1 CD4 T cells accelerate the clearance of pathogens by activating innate immune cells with type 1 cytokines. Type 1 CD4 T cells and CD8 T cells also collaborate to protect the host from intracellular Lm infection. Since CD8 T cells function mainly as cytotoxic T cells and CD69‐positive CD8 T cells increase during Lm‐infection, cytotoxic activity of CD8 T cells was evaluated during Lm‐infection. Although CD8 T cells were activated to produce IFN‐γ, the cytotoxic function of CD8 T cells in Lymphocytic choriomeningitis virus (LCMV) p14 TCR‐transgenic mouse was not augmented by Lm‐infection. Therefore, Lm‐infection differentially influences on cytokine production and cytotoxicity of CD8 T cells.