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The Potent Antibacterial Activity of Sitafloxacin against Fluoroquinolone‐Resistant Clinical Isolates of Vibrio cholerae O1
Author(s) -
Okuda Jun,
Ramamurthy Thandavarayan,
Yamasaki Shinji
Publication year - 2007
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2007.tb03921.x
Subject(s) - sparfloxacin , ofloxacin , ciprofloxacin , vibrio cholerae , microbiology and biotechnology , levofloxacin , antibacterial agent , biology , antibiotics , bacteria , genetics
The in vitro antibacterial activity of sitafloxacin using clinical isolates of Vibrio cholerae O1 was compared to other fluoroquinolones: ciprofloxacin, ofloxacin, sparfloxacin and levofloxacin. Against fluoroquinolone‐resistant O1 strains, sitafloxacin was 4‐ to 16‐fold more effective than other fluoroquinolones at MIC 90 . Against fluoroquinolone‐susceptible O1 strains, the MIC 90 of sitafloxacin was 2‐ to 4‐fold lower than other fluoroquinolones. This suggests sitafloxacin can be used in the treatment of infections caused by V. cholerae O1 strains including the fluoroquinolone‐resistant strains.