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Effects of Phthalate Esters on Dendritic Cell Subsets and Interleukin‐4 Production in Fluorescein Isothiocyanate‐Induced Contact Hypersensitivity
Author(s) -
Maruyama Takashi,
Shiba Takahiro,
Iizuka Hiromi,
Matsuda Tomoko,
Kurohane Kohta,
Imai Yasuyuki
Publication year - 2007
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2007.tb03914.x
Subject(s) - fluorescein isothiocyanate , phthalate , lymph , sensitization , fluorescein , dendritic cell , adjuvant , diethyl phthalate , dibutyl phthalate , chemistry , allyl isothiocyanate , biology , delayed hypersensitivity , isothiocyanate , immunology , biochemistry , medicine , immune system , pathology , organic chemistry , fluorescence , physics , quantum mechanics
Phthalate esters with short alkyl chains, such as di‐ethyl (DEP), di‐ n ‐propyl (DPP), and di‐butyl phthalate (DBP), have adjuvant effects on an FITC‐induced contact hypersensitivity mouse model. The adjuvant effects of DPP and DBP are associated with enhanced trafficking of FITC‐presenting CD11b + dendritic cells (DC). DEP has relatively weak activity as to FITC‐positive cell migration. Here we demonstrated that DBP and DPP also increased the number of FITC‐positive CD8alpha + DC in draining lymph nodes. We also found enhanced production of interleukin‐4 in draining lymph nodes after FITC sensitization with DEP, DPP, or DBP, suggesting an additional adjuvant mechanism of phthalate esters.