Premium
Autoimmune Regulator (AIRE) Gene Is Expressed in Human Activated CD4 + T‐Cells and Regulated by Mitogen‐Activated Protein Kinase Pathway
Author(s) -
Nagafuchi Seiho,
Katsuta Hitoshi,
KoyanagiKatsuta Rimiko,
Yamasaki Satoshi,
Inoue Yasushi,
Shimoda Kazuya,
Ikeda Yukari,
Shindo Mieko,
Yoshida Eiko,
Matsuo Tomohito,
Ohno Yuju,
Kogawa Kazuhiko,
Anzai Keizo,
Kurisaki Hironori,
Kudoh Jun,
Harada Mine,
Shimizu Nobuyoshi
Publication year - 2006
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2006.tb03876.x
Subject(s) - autoimmune regulator , biology , mapk/erk pathway , protein kinase a , mitogen activated protein kinase , p38 mitogen activated protein kinases , kinase , gene expression , microbiology and biotechnology , gene , regulator , regulation of gene expression , immune system , immunology , autoimmunity , biochemistry
The autoimmune regulator (AIRE) gene is a gene responsible for autoimmune polyendocrinopathy‐candidiasis‐ectodermal dystrophy. Here we show that AIRE is expressed in human peripheral CD4‐positive T‐cells, and most highly in antigen‐ and interleukin 2‐stimulated T (IL‐2T) cells. Mitogen‐activated protein kinases (MAPKs), including MAPK kinase (MEK) 1/2 and p38 MAPK, were phosphorylated in IL‐2T cells and the expression of the AIRE gene was inhibited by a specific p38 MAPK inhibitor (SB203580), thereby indicating that AIRE gene expression is controlled by the MAPK pathway in IL‐2T cells. These data suggested the possible significance of the AIRE gene in the peripheral immune system.