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Sensitivity of Rabies Virus to Type I Interferon Is Determined by the Phosphoprotein Gene
Author(s) -
Shimizu Kenta,
Ito Naoto,
Sugiyama Makoto,
Minamoto Nobuyuki
Publication year - 2006
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2006.tb03875.x
Subject(s) - rabies virus , phosphoprotein , virology , virulence , biology , strain (injury) , virus , interferon , gene , microbiology and biotechnology , genetics , anatomy
The growth of a virulent strain of fixed rabies virus, Nishigahara, in mouse neuroblastoma NA cells treated with type I interferon (IFN) was compared with that of a derivative avirulent strain, Ni‐CE. Nishigahara strain was slightly sensitive to IFN treatment but still grew more efficiently than did Ni‐CE strain in IFN‐treated NA cells. Furthermore, a virulent chimeric virus with the phosphoprotein gene from Nishigahara strain in the Ni‐CE genome was less sensitive to IFN treatment than was Ni‐CE strain, indicating that the IFN sensitivity is determined by the phosphoprotein gene of the virus.