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Listeria monocytogenes Induces the Expression of Retinoic Acid‐Inducible Gene‐I
Author(s) -
Imaizumi Tadaatsu,
Sashinami Hiroshi,
Mori Fumiaki,
Matsumiya Tomoh,
Yoshida Hidemi,
Nakane Akio,
Wakabayashi Koichi,
Oyama Chikara,
Satoh Kei
Publication year - 2006
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2006.tb03857.x
Subject(s) - listeria monocytogenes , biology , innate immune system , retinoic acid , macrophage , microbiology and biotechnology , listeria infection , immunity , listeria , immune system , in vitro , virology , immunology , gene , bacteria , biochemistry , genetics
Retinoic acid‐inducible gene‐I (RIG‐I) is considered to play a role in innate immunity against virus infections. We showed by immunohistochemical study that RIG‐I expression is upregulated in vivo in hepatic Kupffer cells and in splenic reticular cells of mice infected with Listeria monocytogenes . Both heat‐killed L. monocytogenes and live L. monocytogenes induced the expression of RIG‐I in cultured RAW264.7 murine macrophage‐like cells in vitro . RIG‐I may also be involved in innate immunity against Listeria infection.