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Immunological Effects of Recombinant Feline Interferon‐ω (KT‐80) Administration in the Dog
Author(s) -
Kuwabara Masato,
Nariai Youko,
Horiuchi Yutaka,
Nakajima Yuko,
Yamaguchi Yu,
Horioka Eriko,
Kawanabe Mikiko,
Kubo Takuya,
Yukawa Masayoshi,
Sakai Takeo
Publication year - 2006
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2006.tb03828.x
Subject(s) - recombinant dna , biology , interferon , immunity , immunology , canine parvovirus , cats , immune system , virology , whole blood , interferon gamma , interferon γ , parvovirus , medicine , virus , biochemistry , gene
The immunological effects of recombinant feline interferon‐ω (rFeIFN‐ω; KT‐80, Toray) were examined on administration to healthy dogs. The activities of whole blood cells, macrophages, and natural killer cells were enhanced. Moreover, the whole blood activity was examined when KT‐80 was administered to dogs which had been diagnosed as having natural canine parvovirus (CPV) infection. Only some cases in which the activity increased until 3 hr post‐administration survived. These results suggest that rFeIFN‐ω (KT‐80) treatment enhanced the cellular immunity of normal dogs, and could exert significant therapeutic effects on only natural CPV infected dogs with induced continuous immunoenhancement.