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Deletion Polymorphisms in the Promoter Region of Fcγ Receptor IIB Is Not Associated with Antigen‐Specific IgG2a and IgG2b Antibody Responses in NC/Nga Mice
Author(s) -
Sakai Tohru,
Kogiso Mari,
Mitsuya Kaori,
Komatsu Tatsushi,
Yamamoto Shigeru
Publication year - 2006
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2006.tb03817.x
Subject(s) - biology , antibody , antigen , receptor , microbiology and biotechnology , immunology , virology , genetics
Fcγ receptor (R) IIB, a low‐affinity FcR for IgG, inhibits B cell Ag R (BCR)‐mediated activation when these two receptors are cross‐linked by Ag and IgG‐containing immune complexs (ICs). We found deletion polymorphisms in the promoter region of fcgr2b in NC/Nga mice, a model for human atopic dermatitis. NC/Nga mice produced significantly higher levels of ovalbumin (OVA)‐specific IgG, IgG2a and IgG2b than did BALB/c mice. Analysis of (BALB/c×NC/Nga)F1×BALB/c or (BALB/c×NC/Nga) F1×NC/Nga backcross mice revealed that deletion polymorphisms of fcgr2b in NC/Nga mice does not directly regulate hyper OVA‐specific IgG2a and IgG2b Ab responses.