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Peroral Infectivity of Toxoplasma gondii in Bile and Feces of Interferon‐γ Knockout Mice
Author(s) -
Piao LianXun,
Aosai Fumie,
Mun HyeSeong,
Yano Akihiko
Publication year - 2005
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2005.tb03725.x
Subject(s) - toxoplasma gondii , feces , biology , infectivity , microbiology and biotechnology , virology , titer , antibody , immunology , virus
Toxoplasama gondii appeared in the bile and feces of interferon‐γ knockout (GKO) but not wild type mice on days 7–8 after peroral infection with T. gondii cysts of Fukaya strain. Both tachyzoite‐specific SAG1 and bradyzoite‐specific T.g .HSP30 mRNAs were detected in the bile and feces of GKO mice. Tachyzoites converted to bradyzoites by culturing in the bile. By feeding uninfected mice with the bile and washed feces of T. gondii ‐infected GKO mice, T. gondii ‐specific antibody formation in the serum and cyst formation in the brain were observed. The novel migration route of T. gondii from liver to bile and feces in GKO mice was confirmed.