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Increased Expression of c‐myc Is Associated with Thymoma in Rats Infected with Murine Leukemia Virus A8
Author(s) -
Hirano Tomoko,
Watanabe Rihito,
TakaseYoden Sayaka
Publication year - 2005
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2005.tb03704.x
Subject(s) - thymoma , provirus , biology , murine leukemia virus , virology , clone (java method) , virus , leukemia , carcinogenesis , enhancer , microbiology and biotechnology , southern blot , cancer research , genome , immunology , gene , gene expression , genetics
Infection of rats with Friend murine leukemia virus (Fr‐MLV) clone A8 causes thymoma in all the animals within 7 weeks. The rapid induction of thymoma is associated with a unique enhancer structure in the U3 region of the A8‐LTR. Our Southern blot analyses showed that the thymomas were oligo clonal. The A8‐induced thymomas showed 3‐ to 11‐fold overexpression of c‐myc mRNA. These results suggest that provirus insertion into particular positions of the host genome is correlated with tumorigenesis after A8 infection and that up‐regulation of c‐myc plays an important role in the induction of thymoma.